丹芍化纤胶囊对肝细胞线粒体脂质过氧化的影响  

The Inhibitory Effect of Danshaohuaxian Capsules on the Peroxidation of Mitochondrion Lipid in Liver Cells of Hepatic Fibrosis Rats

作　　者：伍徐娴[1] 杨勤[1] 罗新华[2] 耿晓霞[3] 时黛[4] 李诚秀[5] 程明亮[3] 

机构地区：[1]贵阳医学院病理生理学教研室,贵州贵阳550004 [2]贵州省人民医院传染科,贵州贵阳550002 [3]贵阳医学院感染病学教研室,贵州贵阳550004 [4]贵阳医学院临床医学系,贵州贵阳550004 [5]贵阳医学院药理学教研室,贵州贵阳550004

出　　处：《贵阳医学院学报》2004年第5期405-406,409,共3页Journal of Guiyang Medical College

基　　金：贵州省特殊人才基金资助( 2 0 0 3 1 )

摘　　要：目的 :观察丹芍化纤胶囊对四氯化碳 (CCl4)中毒性肝纤维化模型大鼠肝细胞线粒体脂质过氧化的作用。方法 :分别提取正常对照组、肝纤维化模型组、自然恢复组、低剂量丹芍化纤胶囊治疗组、高剂量丹芍化纤胶囊治疗组大鼠的肝组织线粒体 ,测定丙二醛 (MDA)的含量。结果 :肝纤维化组及自然恢复组较正常组大鼠肝细胞线粒体MDA含量明显增高 (P <0 0 5 ) ,治疗后 ,高剂量治疗组及低剂量治疗组大鼠肝细胞线粒体MDA含量均较肝纤维化组及自然恢复组明显降低 ,基本恢复正常水平。结论 :丹芍化纤胶囊对肝纤维化大鼠肝脏线粒体脂质过氧化具有一定的抑制作用 ,可能是其发挥抗肝纤维化疗效的机制。Objective: To study the effect of Danshaohuaxian capsules on lipid peroxidation of mitochondria in hepatic fibrosis rats.Methods: Mitochondria were extracted from hepatic cells and content of malondialdehyde (MAD) was determined.Results: The content of mitochondrion MAD was significantly higher in hepatic fibrosis rats than that in control (P<0.05). After treatment with Danshaohuaxian capsule for 8 weeks, the MDA content in hepatic fibrosis rats decreased obviously (P<0.05).Conclusion: Danshaohuaxian capsules can inhibit hepatic fibrosis possibly through its inhibitory effect on lipid peroxidation in mitochondria.

关 键 词：肝硬化 线粒体 肝 丙二醛 脂质过氧化作用 四氯化碳 大鼠 丹芍化纤胶囊 

分 类 号：R285.5[医药卫生—中药学] R575.6[医药卫生—中医学]