以酸活化膨润土催化合成阿司匹林  

Synthesis of acetylsalicylic acid by acid bentonite as catalyst

作　　者：王贵全 陈志勇[2] 

机构地区：[1]罗山金鼎化工有限公司,河南罗山464200 [2]信阳师范学院化学化工学院,河南信阳464000

出　　处：《化学工程师》2004年第10期5-7,共3页Chemical Engineer

摘　　要：以水杨酸和乙酸酐为原料 ,在自制酸化膨润土催化下合成了阿司匹林 ;探讨了催化剂的结构特征及最佳催化条件。结果表明 :酸化膨润土对阿司匹林的合成具有良好的催化活性 ;在最佳工艺条件下 ,收率可达 :90 4 4 %。Acetylsalicylic acid was synthesized from salicylic acid and acetic anhydride catalyzed by chloride acidation bentonite. The texture of bentonite and the best conditions of this synthesize were studied. It shows that the acid catalyst works well on the reaction with efficient activity. The yield of acetylsalicylic acid reached 90.44%.

关 键 词：催化合成 收率 乙酸酐 制酸 催化剂 酸活化 最佳工艺条件 阿司匹林 自制 水杨酸 

分 类 号：TQ225[化学工程—有机化工] R971.1[医药卫生—药品]