高效液相色谱法测定盐酸雷洛昔芬原料药有关物质  

Determination of related substances in raloxifene hydrochloride raw medicine by HPLC

作　　者：金义翠[1] 

机构地区：[1]南京工业大学制药与生命科学学院,南京江苏222006

出　　处：《化学工业与工程技术》2004年第5期56-57,共2页Journal of Chemical Industry & Engineering

摘　　要：建立了盐酸雷洛昔芬原料药有关物质的测定方法。采用十八烷基键合硅胶为填充剂的色谱柱(5μm,6mm×150mm),以乙腈-0.05mol/L乙酸铵(3∶7)为流动相,检测波长286nm。结果表明,盐酸雷洛昔芬主峰与各杂质峰分离度好。The HPLC method for determination related substances of raloxifene hydrochloride raw medicine are established. The chromatographic column(5μm,6 mm×150 mm)filled with the octodecyl-binded silica gel is used, with the mobile phase of acetonitrile- 0.05 mol/L ammonium acetate (3∶7), at the detection wavelength of 286 nm. The result shows that the main peak can be nicely separated from the impurity peak in raloxifene hydrochloride.

关 键 词：盐酸雷洛昔芬 有关物质 高效液相色谱法 

分 类 号：O657.72[理学—分析化学]