国产高效氯氰菊酯原药的亚慢性毒性研究  

Study on subchronic toxicity of homemade β-cypermethrin

作　　者：朱光华[1] 池继梅 马争[1] 王致[1] 唐小江[1] 

机构地区：[1]广东省职业病防治院,广东广州510300 [2]广州市海珠区新滘人民医院,510300

出　　处：《中国职业医学》2004年第5期34-35,共2页China Occupational Medicine

摘　　要：目的　研究国产高效氯氰菊酯的亚慢性毒性。方法　将SD大鼠随机分成 4组 ,高效氯氰菊酯原药剂量为 0、0 67、2 97和 10 84mg·kg-1·d-1,连续 90d摄食染毒。结果　高、中剂量组动物肝、脾、肺、肾等主要脏器有不同程度的病理改变。高剂量组见脑有组织水肿 ,WBC与对照组相比显著减少 (P <0 0 5 )。但低剂量组动物的各观察指标无明显异常。结论　高效氯氰菊酯原药在SD大鼠亚慢性 (90d)经口毒性的最大无作用剂量为 0 67mg·kg-1·d-1。Objective To study the subchronic toxicities of β cypermethrin made in a enterprise in Chnia. Methods SD rats were randomly divided into 4 groups fed with 0, 0 67,2 97 and 10 84 mg·kg -1 ·d -1βcypermethrin respectively for 90 days. Results In the end of the test, the rats in median and high dose groups showed pathologic changes in livers, spleens, lungs and kidneys. The high dose group also showed pathologic changes in brains with WBC reduced significantly ( P <0 05). Conclusion The maximal non effect level of β cypermethrin in the 90 day oral test is 0 67 mg·kg -1 ·d -1 .

关 键 词：SD大鼠 亚慢性毒性 高效氯氰菊酯 国产 最大无作用剂量 观察指标 中剂量 原药 研究 连续 

分 类 号：R996[医药卫生—毒理学] TQ453[医药卫生—药学]