肉苁蓉水提液对D-半乳糖致衰大鼠肝脏氧化损伤保护作用的研究  

Protective effects of water extract of Desertliving cistanche on oxidative damage of liver mitochondria in aging model rat induced by D-gal

作　　者：徐辉[1] 魏晓东[1] 欧芹[1] 张鹏霞[1] 白大芳[1] 王明富[1] 杨晶[1] 李志伟[1] 

机构地区：[1]佳木斯大学基础医学院生化教研室,黑龙江佳木斯154007

出　　处：《黑龙江医药科学》2004年第5期22-23,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的 :观察肉苁蓉水提液对 D-半乳糖致衰大鼠肝脏氧化损伤的保护作用。方法 :采用 D-半乳糖所致衰老模型大鼠 ,灌服肉苁蓉水提液 6周 ,测定肝脏活性氧单位、Ca2 + - ATP酶活性、肝线粒体 MDA含量、PL A2 活性。结果 :肉苁蓉水提液显著提高衰老模型大鼠肝脏活性氧单位、Ca2 + - ATP酶活性 (P <0 .0 1) ,显著降低肝线粒体 MDA含量、PL A2 活性(P<0 .0 1)。结论 :肉苁蓉水提液能提高衰老模型大鼠肝脏抗氧化能力 。Objective: To investigate the anti- oxidation effects of water extract of desertliving cistanche on liver mitochondria of aging model rat induced by D-gal. Methods: We used the aging rat induced by D-gal as research sample given water extract of desertliving cistanche for 6 week. We measured the active oxygen unit and Ca 2+-ATPase activity in rat liver and determined the MDA content,and PLA 2 activity in rat liver mitochondria in an attempt to study the effects of water extract of desertliving cistanche on the above-mentioned indexes. Results: The active oxygen unit, Ca 2+-ATPase activity were obviously increased (P<0.01),while the MDA content and PLA 2 activity were markedly decreased (P<0.01)by giving the water extract of desertliving cistanche. Conclusion: The water extract of desertliving cistanche can postpone aging by raising the liver anti- oxidation function of aging model rat.

关 键 词：肉苁蓉 致衰大鼠 肝脏 氧化损伤 线粒体 

分 类 号：R965.1[医药卫生—药理学] R285.5[医药卫生—药学]