尼尔雌醇对兔的抗着床作用及对子宫胞液雌二醇和孕酮受体的影响  

Anti-implantation Action of Nylestriol and Its Effect on Uterine Cytosol Estrogen and Progesterone Receptor in Rabbits

作　　者：解文[1] 郑钦达[1] 雷刚[2] 邱东生[2] 韩守威[2] 韩字研[2] 

机构地区：[1]华西医科大学组织学与胚胎学教研室 [2]华西医科大学附属第二医院妇产科

出　　处：《华西医科大学学报》1993年第2期163-166,共4页Journal of West China University of Medical Sciences

基　　金：四川省计划生育委员会资助项目~~

摘　　要：本实验研究了尼尔雌醇对兔的抗着床避孕作用。采用葡聚糖—活性炭分离方法测定用尼尔雌醇后子宫胞液雌二醇受体和孕酮受体(ER和PR)含量的变化,用放免法测定早孕兔血浆孕酮水平。结果表明:尼尔雌醇对兔有显著的抗着床作用。服尼尔雌醇后,兔子宫胞液ER含量明显降低(P<0.01),PR含量也降低(P<0.05);血浆孕酮水平无明显变化。结果提示尼尔雌醇的抗着床作用与着床前期子宫胞液ER和PR含量的降低有密切关系。The anti-implantation ac-tion of nylestriol in rabbit was studied.The changes of uterine cytosol estrogenand progesterone receptor (ER and PR)were analysed with the dextron-coatedcharcoal method. Plasm progesterone levelof early pregnant rabbits was measuredby radioimmunoassay. The results showed that oral nylestriol could obviously preventthe early pregnancy of rabbit by anti-implantation of blastocyst. The content ofER decreased in the nylestriol group (P<0.01). The content of PR in nylestriolgroup was lower than that of the controlgroup (P<0.05). No significant differ-ence of plasm progesterone level wasnoted between the control and treatmentgroups. These results suggest that thereis close relationship between the anti-impantation effect of nylestriol and thedecresed content of cytosol ER and PRduring the pre-implantation period.

关 键 词：尼尔雌醇 雌二醇 受体 孕酮 

分 类 号：R965.1[医药卫生—药理学]