维那利酮对离体家兔心室乳头肌动作电位和乳头肌张力影响的同步观察  

Synchronous Investigation of the Effects of Vesnarinone on Action Potential and Muscle Tension of Isolated Rabbit's Ventricular Papillary Muscle

作　　者：林代平[1] 蓝庭剑[1] 

机构地区：[1]华西医科大学基础医学院生理学教研室

出　　处：《华西医科大学学报》1993年第2期156-159,共4页Journal of West China University of Medical Sciences

基　　金：国家"七.五"攻关资助项目

摘　　要：作者同步观察了维那利酮对离体家兔心室乳头肌动作电位、乳头肌张力的影响,并对两者变化加以分析。实验结果显示维那利酮使离体家兔心室乳头肌最大张力、张力最大变化速率和动作电位时程(APT)显著增加;对乳头肌细胞静息电位(RP)、动作电位振幅(APA)、0期去极最大速度(V_(max))均无明显作用。同时,APT延长与最大张力增加经统计学衡量呈正相关关系,提示两者变化属同一机理,可能都与钙内流增加有关。This study adopted intra-celluar microelectrode technique to observesynchronously the effects of vesnarinoneon intracelluar potential and muscle ten-sion of isolated rabbit's ventricular pa-pillary muscle and analysed their varia-tion. The results showed that vesnarinoneincreased the T_(max) (P<0.01) and T(dv/dt)(P<0.01) of isolated rabbit's ventricularpapillary muscle and prolonged the actionpotential time (APT) without obvious effects on RP, APA and V_(max) of papillarymuscle. The relationship between them(r=0.994, P<0.05), suggesting that theirchanges be of the same mechanism andprobably relate to the increase of inwardcalcium current.

关 键 词：维那利酮 心肌张力 心室乳头肌 

分 类 号：R965[医药卫生—药理学]