苦黄颗粒与苦黄注射液治疗病毒性肝炎各46例的比较  

Kuhuang Keli(46 patients) vs Kuhuang Zhusheye (46 patients) in treatment of viral hepatitis

作　　者：李定坤[1] 顾小军[1] 孙薇薇[1] 

机构地区：[1]南京市第二医院肝内科,江苏南京210003

出　　处：《中国新药与临床杂志》2004年第11期760-762,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :比较苦黄颗粒与注射液治疗急、慢性肝炎的疗效。方法 :92例病毒性肝炎病人 ,分为 2组 ,每组 4 6例。颗粒组男性 31例 ,女性 15例 ,年龄(35±s 13)a ,予苦黄颗粒 6 g ,口服 ,每日 3次 ;对照组男性 37例 ,女性 9例 ,年龄 (34± 10 )a ,予苦黄注射液 30mL加入 5 %葡萄糖注射液 5 0 0mL ,静脉滴注 ,每日 1次。疗程均为 4～ 6wk。每隔 14d检查肝、肾功能。结果 :退黄时间颗粒组为 (2 6± 9)d ,有效率 89% (4 1/ 4 6 ) ;对照组退黄时间 (2 3± 11)d ,有效率 91% (4 2 / 4 6 ) ,2组间差异无显著意义 (P >0 .0 5 )。肝、肾功能均有明显改善 ,与治疗前差异有显著意义 (P <0 .0 5 ) ,2组间无差异 (P >0 .0 5 )。不良反应轻微。结论 :苦黄颗粒有良好的退黄、降酶作用 ,不良反应少 ,与苦黄注射液类似 ,可作为治疗病毒性肝炎的一线用药。AIM: To compare the curative effects of Kuhuang Keli and Kuhuang Zhusheye in treatment of viral hepatitis. METHODS:Ninety-two viral hepatitis patients were enrolled in this study and divided into two groups, 46 in each group. The patients in Keli group (M31,F15; age (35±s 13) a) received Kuhuang Keli 6 g, po, tid. The patients in control group received Kuhuang Zhusheye 30 mL added with 5 % glucose injection 500 mL iv,gtt,qd. The courses of treatment were 4-6 wk for both groups with liver and kidney functions test for every 14 d. RESULTS:The periods of jaundice loss were (26±9) d in Keli group and (23±11) d in control group, P>0.05. The curative rate of Keli group was 89 % (41/46) and that of control group was 91 % (42/46), P>0.05.After treatment, the liver and kidney function in two groups were both significantly improved (P<0.01), with no difference between them (P>05). The adverse reactions were rare in both groups. CONCLUSION: Kuhuang keli has good effect in decreasing jaundice and aminotransferase with rare adverse reaction as well as Kuhuang Zhusheye.

关 键 词：肝炎 病毒性 人 黄疸 植物制剂 苦黄颗粒 

分 类 号：R512.6[医药卫生—内科学] R286[医药卫生—临床医学]