MN9202对离体大鼠胸主动脉的舒张作用及其机制  

Vasorelaxing role of MN9202 in rat thoracic artery in vitro

作　　者：朱肖星[1] 梅其炳[1] 张峰[1] 胡玉珍[2] 裴建明[2] 陈定章[3] 吕顺艳[2] 

机构地区：[1]第四军医大学基础部药理学教研室,陕西西安710032 [2]第四军医大学基础部生理学教研室,陕西西安710032 [3]第四军医大学西京医院超声科,陕西西安710032

出　　处：《心脏杂志》2004年第5期421-422,426,共3页Chinese Heart Journal

摘　　要：目的 :研究新合成的二氢吡啶类钙拮抗剂 2 ,6 二甲基 4 (3 硝基苯基 ) 1,4 二氢 3,5 吡啶二羧酸 3 甲酯 5 正戊酯 (MN92 0 2 )对离体大鼠胸主动脉的舒张作用及其机制。方法 :采用离体血管灌流的方法 ,观察MN92 0 2对内皮完整和去内皮胸主动脉的舒张作用 ,以及TEA(四乙铵 )对这一过程的影响。结果 :MN92 0 2可引起剂量依赖性的舒张血管效应且无内皮依赖性 ;钙激活钾通道 (KCa)的阻断剂TEA(10 -5mol/L)可减弱 (但不完全阻断 )MN92 0 2舒张血管的作用 ,使量效曲线右移。结论 :MN92 0 2对胸主动脉具有不依赖内皮的舒张作用 ,此作用是通过阻断L 型钙通道的钙内流 ,本研究也证明MN92 0 2舒张胸主动脉作用可能还与KCa有关。AIM:To investigate the effects and mechanism of methyl pent y1 ,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pridinedicarboxylate (MN92 02, a novel dihydropyidine calcium channel blocker) on blood vessel rings of ra t thoracic arteries. METHODS:Effects of MN9202 on the tension of vascular strips were observed by n vitro perfusion. The effects of TEA were also observed. RESULTS:It was found that MN9202 caused a concentr ation-dependent relaxation in rat thoracic arteries which was independent of th e endothelium. TEA(10 -5mol/L),an antagonist of calcium activated potassiu m channel(K Ca) reduced but not completely blocked the vasorelaxing effec t of MN9202. CONCLUSION: These findings suggest that MN9202 can re lax rat thoracic arteries and the vasorelaxing effect of MN9202 is associated wi th K Ca.

关 键 词：MN9202 大鼠 胸主动脉 舒张作用 机制 氯化四乙铵(TEA) 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]