1,6-二磷酸果糖治疗扩张性心肌病急性心力衰竭的疗效  

Curative effects of 1,6-FDP on acute heart failure caused by dilated cardiomyopathy

作　　者：蔡广[1] 李国璋[1] 吉俭[1] 黄燕平[1] 

机构地区：[1]解放军303医院心内科,广西南宁530021

出　　处：《心脏杂志》2004年第5期457-458,461,共3页Chinese Heart Journal

摘　　要：目的 :观察 1,6 二磷酸果糖 (FDP)治疗扩张性心肌病 (DCM)急性心力衰竭 (心衰 )的疗效。方法 :将 6 2例DCM并发急性心衰患者随机分成FDP组和对照组 ,对照组给予常规治疗 ;FDP组在对照组治疗基础上加用FDP静脉滴注 (5g ,每日 2次 ,10d) ,10d后观察心功能变化及用心脏二维超声测定心脏结构变化。结果 :FDP组DCM心衰患者心功能纠正总有效率为 97% (30 /31) ,明显优于对照组的 81% (2 5 /31) ,超声测定的左室射血分数、心脏指数、每搏量、左室收缩末期内径、左室舒张末期内径比治疗前好转 ,效果优于对照组。结论 :FDP对DCM急性心衰有明显的疗效。AIM:To study the curative effects of 1,6-FDP on acute h eart failure caused by dilated cardiomyopathy(DCM). METHODS:62 DC M cases were divided into two groups:the control group :31 cases treated with conventional therapy and the FDP group: 31 cases ,treated with conventional th erapy plus 1,6-FDP(5 g,iv,bid, 10 days). The changes in cardiac function were o bserved and cardiac function and changes in left ventricular morphology were inv estigated with ultrasonography before and after 10 days’ treatment. RE SULTS:The total rate of significant improvement of heart function in hea rt failure patient with DCM was 97%, which was significantly higher than that in the control group (81% ,25/31). After 10 days' treatment, LVEF, CI,SV, LVESd and LVEDd were significantly improved in the FDP group as compared with the c ontrol group. CONCLUSION:FDP has significant effects on heart fai lure caused by dilated cardiomyopathy.

关 键 词：1 6-二磷酸果糖 扩张性心肌病 心力衰竭 治疗 

分 类 号：R542.2[医药卫生—心血管疾病] R541.6[医药卫生—内科学]