何首乌提取物二苯乙烯苷对东莨菪碱致学习记忆障碍模型小鼠的影响  

Effect of 2,3,5,4'—tetrahydroxystilbene—2—O—β—D—glucoside on the Learning and Memory Ability of Mouse Dementia Models Induced by Scopolamine

作　　者：叶翠飞[1] 魏海峰[1] 张丽[1] 张兰[1] 李林[1] 

机构地区：[1]首都医科大学宣武医院药理研究室,北京市100053

出　　处：《中国药房》2004年第11期658-660,共3页China Pharmacy

基　　金：国家重点基础研究发展计划("973"项目)(G200057010);北京市科委资助首都"248"重大创新工程项目(H01021013011);北京市重点科技实验室项目(951890600);北京中医药管理局资助北京市中医药重点学科项目(2001)

摘　　要：目的观察何首乌提取物二苯乙烯苷(TSG)对东莨菪碱致学习记忆障碍模型小鼠的影响。方法将小鼠随机分为空白对照组、模型组、TSG组(低、高剂量组)和阳性对照组(吡拉西坦),分别灌胃给药,之后造模并进行Morris水迷宫测试和避暗测试。结果与模型组小鼠比较,在Morris水迷宫测试中,空白对照组、阳性对照组及TSG高剂量组小鼠搜索时间及搜索距离均明显缩短(P<005);在避暗测试中,TSG组小鼠受电击次数明显减少(P<005),潜伏期延长。结论何首乌提取物TSG对东莨菪碱所致小鼠学习记忆障碍具有一定的改善作用。OBJECTIVE:To investigate the effect of 2,3,5,4'—tetrahydroxystilbene—2—O—β—D—glucoside(TSG) on the learning and memory ability of mouse dementia models induced by scopolamine METHODS:Mice were randomly divided into blank group,model group,TSG groups(low dose,high dose) and positive control(Piracitam) group All the mouse were intragastrically administrated by drugs After making model,all mice were subjected to Morris water maze and passive avoidance tests RESULTS:Compared with model group,swimming time were significantly reduced in the blank group,positive control group and high dose of TSG group during Morris water maze test (P<0 05) TSG could prolong latency of the mouse dementia models and reduce error times during step through test CONCLUSION:TSG can effectively improve the learning and memory ability of dementia mice induced by scopolamine

关 键 词：二苯乙烯苷 东莨菪碱 学习记忆障碍 小鼠模型 

分 类 号：R965[医药卫生—药理学]