阿霉素-聚乳酸眼用缓释植入片的制备及质量控制  

Preparation and Quality Control of Slow-released Implantable Adriamycin Tablets

作　　者：范佳清[1] 涂运输[1] 丁勇[1] 

机构地区：[1]重庆市急救医疗中心药剂科,重庆市400014

出　　处：《中国药房》2004年第11期662-663,共2页China Pharmacy

摘　　要：目的制备阿霉素-聚乳酸眼用缓释植入片,并建立其质量控制标准。方法以聚乳酸为载体制备阿霉素-聚乳酸缓释植入片,并以紫外分光光度法测定植入片中盐酸阿霉素的含量;将其植入兔眼中进行实验。结果阿霉素-聚乳酸缓释植入片平均重量为456mg,盐酸阿霉素在086～1072μg/ml浓度范围内线性关系良好(r=09993),平均回收率为9920%,RSD=043%(n=5)。结论阿霉素-聚乳酸缓释植入片制备工艺简单,质控方法可行。OBJECTIVE:To prepare the slow_released implantable adriamycin tablets and to establish the standard of quality control METHODS:Slow_released implantable adriamycin tablets were prepared with polylactic acid as carrier and were implanted into rabbit’s eyes for observation UV_spectrophotometer was used to determine the content of adriamycin in impla_ntable tablet RESULTS:The average weight of the implantable tablet was 4 56mg The absorption value and concentration showed a good linearity in a range of 0 86～10 72μg/ml(r=0 9 993) The average recovery was 99 20%,RSD=0 43%(n=5) CONCLUSION:The slow_released adriamycin tablet is simple in preparation technic and feasible in quality control method

关 键 词：阿霉素 聚乳酸 缓释植入片 制备 质量控制 

分 类 号：R943[医药卫生—药剂学] R979.1[医药卫生—药学]