诱导心脏发生的早期信号通路  

Early Signaling Pathways During Cardiogenesis

作　　者：王春梅[1] 姜涛[1] 周春燕[1] 

机构地区：[1]北京大学基础医学院生物化学与分子生物学系,北京100083

出　　处：《中国生物化学与分子生物学报》2004年第5期572-577,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家高技术研究发展计划 ( 863计划 )基金 (No .2 0 0 1AA2 160 3 13 );北京市科技计划重大项目基金 (No .H0 2 0 2 2 0 0 10 490 );教育部 2 11工程项目;北京大学 985基金资助项目~~

摘　　要：心脏是胚胎发生过程中最早形成的器官 .心脏前体的特化是组织间及细胞与细胞之间相互作用的结果 ,这一过程包含了诱导信号作用的时间和空间完整程序 .以脊椎动物和无脊椎动物作为模式动物 ,总结了在早期心脏发生中发挥重要作用的诱导信号通路 :BMP Dpp ,Wnt Wingless ,FGF及Notch信号通路 ,并阐述了信号通路之间的通讯 (crosstalk)以及信号通路与心脏发生相关的关键转录调节因子之间的协同诱导作用 .The heart is the first organ to form during embryogenesis. The specification of heart precursors is a result of multiple tissues and cell-cell interactions that involve temporally and spatially integrated programs of inductive signaling events. The functions of the major signaling pathways BMP/Dpp,Wnt/Wingless,FGF and Notch are summarized during early cardiogenesis in both vertebrate and invertebrate models. The crosstalk among inductive signaling pathways and the relationships between signaling and cardiogenic transcriptional regulators that cooperate to control cardiac induction is also discussed in this review.

关 键 词：心脏发生 信号通路 BMP/Dpp Wnt/Wingless FGF NOTCH 

分 类 号：Q593[生物学—生物化学] Q132.7