人肺腺癌多药耐药细胞系SPC-A1/TAX的耐药机制初探  

The Initial Analysis of the MDR Mechanism in the Human Lung Adenocarcinoma Subline SPC-A1/TAX

作　　者：童波[1] 李羲[1] 邱小华[1] 饶纬华[1] 

机构地区：[1]江西医学院第二附属医院呼吸内科,江西南昌330006

出　　处：《江西医学院学报》2004年第5期23-24,共2页Acta Academiae Medicinae Jiangxi

摘　　要：目的　初步探讨人肺腺癌多药耐药细胞系SPC A1/TAX的耐药机制。方法　免疫组织化学S P染色法检测多药耐药基因mdr1的表达产物P 糖蛋白 (P gp)。结果　在人肺腺癌多药耐药细胞系SPC A1/TAX与其亲本细胞系SPC A1中P gp的表达均为阴性。结论　该多药耐药细胞系的多药耐药性 (MDR)表型可能是非PObjective To explore the mechanism of multi-drug resistance(MDR) in the human lung adenocarcinoma MDR subline SPC-A1/TAX.Methods The expressions of P-glycoprotein(P-gp)in these two cell lines were detected by immunocytochemistry staining.Results The immunocytochemistry staining of P-gp showed negative in both cell lines.Conclusion The human lung adenocarcinoma MDR subline SPC-A1/TAX is probably a non-P-gp MDR cell line.

关 键 词：人肺腺癌细胞系 多药耐药性 紫杉醇 P-糖蛋白 

分 类 号：R969[医药卫生—药理学] R734.2[医药卫生—药学]