血小板计数异常与疾病关系的探讨  

Relationship between Platelet Count and Diseases

作　　者：连惠红[1] 林敏[1] 朱绿绮[1] 徐南平[1] 章武强[1] 

机构地区：[1]江西省儿童医院PICU,江西南昌330006

出　　处：《江西医学院学报》2004年第5期73-74,77,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的　探讨血小板计数 (PC)在炎性疾病中的消长规律以及与预后的关系。方法　回顾性调查自 2 0 0 1年 6月至 2 0 0 2年 12月入住江西省儿童医院PICU的 78例测定二次以上的血小板计数异常儿 ,把PC <10 0× 10 9/L归入PC减少组 ,PC >35 0× 10 9/L归入PC增高组 ,调查其原发病 ,了解PC异常与病程以及预后的关系 ,观察PC与WBC、RBC三者之间的关系。结果　 78例中 6 5例为PC升高组 ,最高为 2 0 0 0× 10 9/L ,13例为PC减少组 ,最低为 2 0× 10 9/L ,二组各死亡 2例 ,死亡率分别为 3.0 7%和 30 .76 % ,有非常显著差异 (P <0 .0 1)。PC升高组的死亡儿均死于不可逆的原发病 ,似于PC升高的炎性反应无关 ;PC减少组均死于多器官功能障碍 (MODS) ,2例在短时间内下降 >5 0 % ,而存活儿的PC均升至 10 0× 10 9/L以上。未见PC、WBC和RBC三者之间的消长规律。结论　PC升高提示炎性反应 ,在危重儿中PC常降低 ,猜测下降的原因主要是因为DIC时消耗增加以及在内脏器官中扣押 ,其下降的程度和速度以及再次升高的快慢与预后有关 ,PC易监测、价廉 。Objective To study the relationship between platelet count(PC)and diseases.Methods Seventy-eight cases were retrospectively reviewed,who were hospitalized in PICU of Jiangxi Children's Hospital with abnormal PC at least 2 times during Jun.2001 to Dec.2002. The patients were divided into PC increasing(PCI >350×10 9/L) and PC decreasing(PCD <100×10 9/L)groups.Results There were 65 cases in PCI with 2 cases died of irreversible primary diseases and 13 cases in PCD with 2 cases having a large decrease in PC died of sepsis and pneumonia with severe multiple organ dysfunction. The mortality was 3.07% in PCI vs 30.76% in PCD.However,the PC of those survivors were gradually increasing to more than 100×10 9/L.Conclusion Platelet number is a marker of inflammation.Thrombocytopenia appears to be a predictor of mortality in PICU.A large decrease in PC indicates poorer vital prognosis.

关 键 词：血小板 疾病 儿童 

分 类 号：R558[医药卫生—血液循环系统疾病]