微小模型与正糖钳夹术对正常人群胰岛素敏感性的检测及相关性  

Compare insulin sensitivity index of hyperinsulin euglycemic clamp with that of mini-model in normal population

作　　者：陈宇红[1] 毕宇芳[1] 陈惠敏[1] 张连珍[1] 洪洁[1] 胡仁明[1] 赵咏桔[1] 宁光[1] 

机构地区：[1]上海第二医科大学瑞金医院内分泌科上海市内分泌代谢病临床医学中心,上海200025

出　　处：《上海第二医科大学学报》2004年第9期749-750,761,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市教委曙光计划(01SG48)资助项目.

摘　　要：目的 探讨微小模型技术与高胰岛素正葡萄糖钳夹技术在正常人群中检测胰岛素敏感性的相关性。方法 对志愿者进行口服葡萄糖耐量试验,正常者入选并分别接受微小模型试验和高胰岛素正葡萄糖钳夹试验,两者相隔1周。计算两种方法所测定的胰岛素敏感性指数并进行相关性比较。结果 微小模型技术胰岛素敏感性指数为6.81±4.27,钳夹技术所计算的葡萄糖利用率为7.84±2.69,两者呈明显正相关(r=0.742,P<0.001)。结论 在正常人群中微小模型技术与正葡萄糖钳夹技术检测胰岛素敏感性存在极好的相关性。Objective To explore the relationship between mini-model technique and hyperinsulin euglycemic clamp in evaluating insulin sensitivity in healthy population. Methods All subjects have OGTT at first. If they are normal, then mini-model and clamp tests are carried out with an interval of one week. Calculate and compare the index of insulin sensitivity. Results The index of insulin sensitivity in mini-model was 6.81 ±4.27, while in clamp was 7. 84 ±2. 69; the relationship was r = 0. 742 (P<0.001). Conclusion In normal population there is excellent relationship of insulin sensitivity index between mini-model and hyperinsulin euglycemic clamp.

关 键 词：正常人群 胰岛素敏感性指数 微小模型技术 相关性 钳夹术 高胰岛素 葡萄糖 钳夹技术 性比 

分 类 号：R587[医药卫生—内分泌] R-332[医药卫生—内科学]