山楂黄酮对实验性大鼠急性心肌缺血保护作用的研究  

Protective effects of Hawthorn flavonoid on rat with acute myocardial ischemia

作　　者：崔新羽[1] 崔新颖[1] 

机构地区：[1]北华大学医学院,吉林132001

出　　处：《中国地方病防治》2004年第5期275-276,共2页Chinese Journal of Control of Endemic Diseases

摘　　要：目的　通过山楂黄酮对抗大鼠急性心肌缺血的试验研究 ,观察山楂黄酮是否对大鼠急性心肌缺血具有保护作用。方法　Wistar大鼠 40只 ,随机分成 4组 ,山楂黄酮组每天灌胃给药 1次 ,低剂量组 0 .5g/kg ,高剂量组 1g/kg ,连续 7d ,末次给药 60min后 ,观察静脉注射垂体后叶素后心电图ST段上移和T波升高的幅度及出现心律失常的动物数。结果　不同剂量的山楂黄酮均可明显减轻实验性大鼠急性心肌缺血的心电图改变及减少大鼠心律失常的发生率。Objective To observe the protective effects of hawthorn flavonoid on rat with acute myocardial ischemia in the experiment.Methods 40 Wistar rats were divided into 4 groups at random,hawthorn flavonoid groups:low dose 0.5 g/kg,high dose 1.0 g/kg,perfusion stomach hawthorn flavonoid for 7 days.After 1 hour of last time's perfusion,we observed the rats number after intravenous IV posterior pituitary hormones of ECG s-t and t wave ascend amplitude and arrhythmia.Results Different dose's hawthorn flavonoid could significantly decrease rat acute myocardial ischemia ECG change and arrhythmia.Conclusion Hawthorn flavonoid has protective effects on rat with acute myocardial ischemia.

关 键 词：山楂黄酮 急性心肌缺血 实验性大鼠 保护作用 心电图 心律失常 观察 结论 目的 对抗 

分 类 号：R259.43[医药卫生—中西医结合] R151.1[医药卫生—中医内科学]