血液稀释疗法对小型猪严重烧伤后血液流变学特性的影响  

Effects of hemodilution therapy on the hemorrheologic characteristics of mini pigs after severe burn

作　　者：徐刚[1] 刘军[1] 李凤山[1] 陈树强[1] 冯玉柱[1] 刘冬梅[1] 杜秀红[1] 高潮[1] 孙拥新[1] 

机构地区：[1]唐山工人医院烧伤整形科,河北省唐山市063000

出　　处：《中国临床康复》2004年第29期6380-6381,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:通过中国实验用小型猪严重烧伤后应用血液稀释疗法,探讨其对血液流变学特性的影响,为血液稀释疗法的临床应用提供理论依据。方法:严格选择20只中国实验用小型猪制作严重烧伤动物模型,随机分为对照组及实验组,按烧伤前、伤后,,,,68162448h,6个时相分别检测全血黏度、血细胞比容、红细胞变形指数、红细胞聚集指数等指标。结果:实验组全血黏度、血细胞比容、红细胞聚集指数等血液流变学指标与对照组相比明显降低,红细胞变形指数明显增加。结论:在烧伤休克期及围手术期应用血稀疗法可明显减轻烧伤休克期血液浓缩、红细胞聚集与黏滞,提高红细胞变形能力,有效改善血容量。血液稀释疗法在烧伤休克期及围手术期是一种可行有效的治疗措施,对大面积烧伤早期修复及临床治愈率提高有重要的指导意义。AIM:To investigate the effect of hemodilution therapy on hemorrheologic characteristics by using the therapy on the experimental Chinese mini pigs after severe burn, and provide a theoretical basis for clinical application of hemodilution therapy. METHODS:Twenty experimental Chinese mini pigs were selected to establish the severe burn animal models, and then randomly divided into two groups: control group and experimental group. The levels of viscosity of whole blood, hematocrit(Hct), erythrocytic deformation index and erythrocytic aggregation index were measured before and 6, 8, 16, 24 and 48 hours after burn. RESULTS:The hemorrheologic indexes such as the viscosity of whole blood, Hct and erythrocytic aggregation index in the experimental group were obviously lower than those in the control group, but the erythrocytic deformation index significantly increased. CONCLUSION:The application of hemodilution therapy in burn shock stage and perioperative stage can obviously relieve the concentration of blood, erythrocytic aggregation and viscosity in burn shock stage, and also promote the ability of erythrocytic deformation and improve the blood volume effectively. So it is a feasible and effective treating measure in burn shock stage and perioperative stage.It has an important significance on the early rehabilitation of burn wound with a large area and the promotion of clinical healing rate.

关 键 词：血液稀释疗法 严重烧伤 小型猪 血液流变学 全血黏度 血细胞比容 红细胞变形指数 严格 结论 实验 

分 类 号：R644[医药卫生—外科学] R743[医药卫生—临床医学]