N-取代去甲基斑蝥酰亚胺及其类似物的合成  

Synthesis of N-substituted norcantharidinimide and analogues

作　　者：程石泉[1] 乌力吉木仁[1] 王佩珠[1] 曹锦江 李凤英 

机构地区：[1]内蒙古医学院药学系,呼和浩特010059

出　　处：《化学试剂》1993年第1期1-4,共4页Chemical Reagents

摘　　要：合成了 N-取代去甲基斑蝥酰亚胺、去甲基斑蝥素等23种化合物,对其结构做了元素分析。Norcantharidinimide,7-oxabicyclo[2.2.1]heptane-2,3-dicarboximide Ⅲ,and its dehydroderivatives,7-oxabi-cyclo[2.2.1]hept-5-ene-2,3-dicarboximide derivativesⅠ,Ⅱ were prepared by aminolysis of norcantharidine withpseudonorephedrine and other primary amines and also byN-Mannich reaction of the unsubstituted imide with cor-responding primary or secondary amines in the presence offormaldehyde in 95% ethyl alcohol.Twenty-three new norcantharidinimide derivativeswere obtained in good yields.All compounds were charac-terized by elemental analysis and IR spectra.

关 键 词：去甲基斑蝥素 酰亚胺 抗癌药 

分 类 号：R979.1[医药卫生—药品]