水杨醛-5-烯去甲基斑蝥腙及其类似物的合成  

Synthesis of salicylaldehyde-5-ene-norcantharidinhydrazone analogues

作　　者：程石泉[1] 乌力吉木仁[1] 吴晓英 张秀杰 

机构地区：[1]内蒙古医学院药学系,呼和浩特010059

出　　处：《化学试剂》1993年第3期152-154,共3页Chemical Reagents

摘　　要：8种水杨醛-5-烯去甲基斑蝥腙及其类似物由 N-氨基-5-烯去甲基斑蝥胺分别与水杨醛、肉桂醛、苯甲醛、邻硝基苯甲醛、N,N-二甲氮基苯甲醛、苯乙酮、2-(6-甲氧基)萘乙酮和乙酰乙酸乙酯在无水乙醇溶液中进行缩合反应而制得,这些缩合产物具有敏锐的熔点。元素分析和红外图谱确定了其结构,证明都是首次合成的新化合物。Eight salicylaldehyde-5-ene-norcanthari dinhydrazone and analogus(1～8)were prepared from N-amino-5-ene-norcantharidin amine by condensation with sali-cylaldehyde,cinnamylaldehyde,benzaldehyde,o-nitro-benzaldehyde,N,N-dimethylaminobenzaldehyde,ace-tophenone,2-(6-methoxy)-acetonaphthone and ethylacetoacetate respectively in absolute ethanol for two tothree hours.The condensation products possess sharpmelting points.The structures of all the compoundssynthesized were confirmed by elementary analysis andIR spectra.

关 键 词：水杨醛 斑蝥腙 缩合反应 

分 类 号：TQ463.5[化学工程—制药化工]