N-取代邻苯二甲酰亚胺衍生物的合成  

Synthesis of N-substituted phthalimide derivatives

作　　者：乌力吉木仁[1] 程石泉[1] 张秀杰 吴晓英 

机构地区：[1]内蒙古医学院药学系,呼和浩特010059

出　　处：《化学试剂》1993年第4期244-245,247,共3页Chemical Reagents

摘　　要：合成了12种N-取代邻苯二甲酰亚胺衍生物。以邻苯二甲酰亚胺为母体,38%甲醛-95%乙醇为溶剂,分别与脂肪胺和芳香胺加热回流,合成了12种N-Mannich 碱。所制得化合物的熔点敏锐。元素分析和红外光谱分析表明,12种化合物均为首次合成的新化合物。Twelve derivatives of N-substituted phthalimidehave been synthesized through the N-Mannich reac-tion of phthalimide respectively with morpholine,cy-clohexylamine,n-butylamine,aniline,o-methylani-line,2,3-dimethylaniline,p-chloroaniline,N-methy-laniline,diphenylamine,p-aminobenzoic acid,m-aminobenzoic acid and (-)-ephedrine hydrochloride.The new derivatives of N-Mannich base possess sharpmelting points.The structures of these new com-pounds have been confirmed by elemental analysis andIR spectra.

关 键 词：苯二甲酰亚胺 合成 

分 类 号：O625.632[理学—有机化学]