透明质酸外敷膜对大鼠手术切口愈合的影响  

The effect of hyaluronic acid external film on rats wound healing

作　　者：任贵云[1] 董福生[1] 王洁[2] 石培凯[1] 

机构地区：[1]河北医科大学口腔医学院口腔颌面外科,石家庄050017 [2]河北医科大学口腔医学院口腔病理科,石家庄050017

出　　处：《中华整形外科杂志》2004年第5期380-383,共4页Chinese Journal of Plastic Surgery

基　　金：河北省博士资金资助 ( 0 3 5 470 0 7D)

摘　　要：目的　探讨透明质酸外敷膜对手术切口愈合的影响。方法　选用纯系SD大鼠 4 8只 ,随机分为 8组 ,每组 6只。采用背部两侧切口 ,左侧外敷透明质酸膜 ,为实验组 ;右侧外敷生理盐水纱条作为对照。分别对术后 1～ 2 8d切口愈合情况进行组织学观察。结果　实验组炎症反应轻 ,表皮愈合快 ,成纤维细胞发生退行样变化 ,胶原纤维较纤细 ,排列较疏松。结论　透明质酸外敷膜在切口愈合早期 ,有较强的透皮作用 ;并可促进表皮层愈合、延缓角化层形成。Objective To observe the effect of an external film of hyaluronic acid (HA)on the rats wound healing. Methods Forty-eight SD rats were randomly separated into eight groups of 6 rats each. Bilateral dorsal cuts were performed on each rat,left wound was used as the experiment with HA external film and right wound was used as the control only with normal saline. The process of healing was observed histologically following 1st, 3rd, 5th, 7th, 9th, 14th, 21st,and 28th days postoperatively. Results Inflammation was lighter and epidermal healing was faster in the experimental group than those in the control. The fibroblasts degenerated and the collagen fiber changed to slim and loose bunches in the experimental group. Conclusion The results indicated that HA external film could have powerful infiltrating activity at the early stage of wound healing,it could accelerate the healing of epidermis and delay the formation of keratinization layer. ;

关 键 词：外敷 切口愈合 透明质酸 手术切口 SD大鼠 延缓 透皮作用 表皮 成纤维细胞 组织学观察 

分 类 号：R619[医药卫生—外科学]