紫外分光光度法测定盐酸二甲双胍缓释片含量  

Quantitative Determination of Metformin Hydrochloride Controlled-release Tablets by Ultroviolet Spectrophotometry

作　　者：杜力巍[1] 杨卫东[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003

出　　处：《河南科技大学学报（医学版）》2004年第1期21-22,共2页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的　建立盐酸二甲双胍缓释片的含量测定方法。方法　采用紫外分光光度法测定 ,用水作溶剂 ,测定波长为 2 3 3nm。结果　在 0 .5 0 3～ 2 0 .1 2 μg/ml浓度范围内 ,线性关系良好 ,平均回收率为 99.44%。结论　本方法准确、灵敏 ,快速 。Objective To establish a quantitative determination method of metformin hydrochloride controlled-release tablet. Methods Metformin hydrochloride controlled-release tablet was determined in water by ultraviolet spectrophotometry. The wave length of detection was 233 nm. Results The calibration curve was linner in the range from 0.503～20.12 μg/ml,the average recovery was 99.44%. Conclusion The method is accurate, sensitive, rapid, and can be used to determine the quantitation of metformin hydrochloride controlled-release tablet.

关 键 词：紫外分光光度法 含量测定 盐酸二甲双胍缓释片 降糖药 

分 类 号：R927.2[医药卫生—药学]