配合物的稳定性与配体碱性之间的直线自由能关系 铜(Ⅱ)—芬布芬—α—氨基酸三元体系  

LINEAR FREE ENERGY RELATIONSHIP BETWEEN STABILITY CONSTANTS OF COMPLEX COMPOUNDS AND BASICITY OF LIGANDS-Cu(Ⅱ)-FENBUFEN-α-AMINOACID TERNARY SYSTEM

作　　者：田君濂[1] 李延团[1] 刘树祥[1] 

机构地区：[1]曲阜师范大学化学系,山东曲阜市273165

出　　处：《化学研究与应用》1993年第1期61-65,共5页Chemical Research and Application

摘　　要：在25±0.1℃,I=0.1mol·l^(-1)KNO_3条件下,在80%(V/V)DMSO—H_2O混合溶剂中,应用pH法测定了DL—苯丙氨酸、甘氨酸、L—缬氨酸、L—丝氨酸、L—异亮氨酸、L—脯氨酸等α—氨基酸的电离常数;铜(Ⅱ)—α—氨基酸二元配合物和铜(Ⅲ)—芬布芬—α—氨基酸三元配合物的稳定常数。使用的α—氨基酸均为生化试剂。实验发现,在Logβ_(102)与pK_b^B,logβ_(111)与pK_2~B及logβ_(111)与olgβ_(102)三对参数之间均存在良好的直线自由能关系。用ΔlogK和Δlogβ_(111)表征了三元混配型配合物相对于二元母体配合物的稳定性.讨论了溶剂的性质、配体之间的堆积作用和疏水作用对配合物稳定性的影响。The dissociation Constants of a—aminoacid and formation constants of Cu(Ⅱ )-a—aminoacid binary complexes and Cu(Ⅱ)—Fenbufen(A)-a—aminoacid(B) ternary complexes at 25±0. 1℃ in the presence of 0. 1mol·dm^(-3)KNO_3,in 80% (V/V) DMSO-H_2O mixed solvent have been determined by pH measurement. The a—aminoacids used were glycine, L-Valine,L-lsolecine,Lerine,DL-phenylalanine and L-proline. It has been found that linear free energy relationships (LFER) exist between the following parameter pairs:logβ_(102) and pK_2~B,logβ_(111) and pK_2~B and logβ_(111) and logβ_(102). △logK and Alogβ_(111) are used to Characterize stability of ternary oomplexes related to stability of binary parent Complexes. The factors contributing to the stability of the binary and ternary complexes are discussed.

关 键 词：芬布芬 络合物 稳定性 配体 碱性 

分 类 号：O641.4[理学—物理化学]