血管紧张素转换酶抑制剂与血管紧张素Ⅱ受体拮抗剂对动脉内膜损伤后增生的影响  

Effects of angiotensin converting enzyme inhibitor and angiotensin Ⅱ antagonist receptor on neointima hyperplasia after vascular balloon injury

作　　者：王晔玲[1] 赵利华[1] 张京平[2] 暴淑英 

机构地区：[1]吉林大学第一医院心内科,吉林长春130021 [2]吉林大学第一医院药剂科,吉林长春130021 [3]吉林省榆树市人民医院内科,吉林榆树130025

出　　处：《吉林大学学报（医学版）》2004年第5期724-726,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题 (吉科合字第 990 5 81- 3号 )

摘　　要：目的 :观察血管紧张素转换酶抑制剂 (ACEI) captopril与血管紧张素 (Ang )的 AT1 受体拮抗剂 valsartan对损伤动脉内膜增生的影响。方法 :以兔右颈总动脉内膜剥脱为实验模型 ,随机分为单纯损伤组、captopril组及 valsartan组。captopril组及 valsartan组术前 1d至术后 14 d分别给予 captopril 2 mg· kg- 1 · d- 1 与valsarta10 mg· kg- 1· d- 1 ,单纯损伤组不给药。检测各组术前及术后 7、 14 d血浆组织纤溶酶原激活物 (t- PA)、纤溶酶原激活剂抑制物 - 1(PAI- 1)、血浆内皮素 (ET)水平 ,并于术后 14 d对各组血管内膜厚度及管腔狭窄度行病理形态学观察。结果 :captopril组及 valsartan组血浆 PAI- 1、ET水平及内膜的厚度、管腔狭窄度均明显低于单纯损伤组 (P<0 .0 5 )。结论 :captopril与 valsartan均可抑制动脉损伤后内膜的增生。Objective To study the effects of angiotensin converting enzyme inhibitor(captopril) and angiotensin Ⅱ antagonist receptor (valsartan) on neointima hyperplasia after vascular balloon injury. Methods Thirty-six rabbit models were randomly divided into three groups:injuried group,captopril group and valsartan group. Captopril (2 mg·kg -1 ·d -1 po) and valsartan (10 mg·kg -1 ·d -1 po) were given to twelve rabbits respectively from 1 day before the right carotid arteries were injuried by 2.0 mm ballon cathether to 14 days after injury in captopil group and valsartan group. The medicine was not administered in the injuried group. The tissue plasminogen activator (tPA),plaminogen activor inhibitor-1(PAI-1) antigen level and plasma endothelin (ET) levels were measured before injury, and 7,14 days after vascular injury. The pathomorphoiogical examination were carried out 14 days after angioplasty. Results The levels of plasma PAI-1 and ET in captopril group and valsartan group were significantly lower than those in the injuried group(P<0.05).The intimal thickness and extent of lumen stenosis in captopril and valsartan groups were significantly lower than those in the injuried group (P<0.05) . Conclusion Captopril and valsartan can inhibit neointima hyperplasia after vascular ballon injury.

关 键 词：血管紧张素转换酶抑制药 血管紧张素I 拮抗剂和抑制剂 血管内膜 损伤 增生 

分 类 号：R972[医药卫生—药品] R-332[医药卫生—药学]