急性时相蛋白及细胞因子测定在2型糖尿病中的应用及临床意义  

Measurement and clinical significance of acute-phase serum proteins and cytokines in patients with type 2 diabietes

作　　者：尹正[1] 崔连东[2] 

机构地区：[1]中国医科大学第二临床学院检验科,沈阳市110004 [2]辽宁省人民医院检验科,沈阳市110016

出　　处：《实用医学杂志》2004年第10期1181-1182,共2页The Journal of Practical Medicine

摘　　要：目的 :探讨急性时相蛋白 (α1 AG、CP)及细胞因子 (IL 6、TNF α)在 2型糖尿病中的作用及临床意义。方法 :分别采用速率散射比浊法和化学发光法测定 91例糖尿病 (DM )患者血清中细胞因子白细胞介素 6(IL 6)、肿瘤坏死因子 α(TNF α)和急性时相蛋白α1酸性糖蛋白 (α1 AG)、铜兰蛋白 (CP)的含量 ,并用 3 0例正常人作对照。结果 :DM患者血清中IL 6、TNF α水平及α1 AG、CP含量明显高于正常对照组 ,且DM并发症组其含量明显高于无并发症组 (P <0 0 1或P <0 0 5 )。结论 :细胞因子IL 6、TNF α及急性时相蛋白α1 AG、CP对DM及DM并发症的发生、发展均起到重要的作用。Objective To explore the change and th e effect of interleukin-6(IL-6), serum tumor necrosis factor(TNF-α) and al pha 1-acid glycoprotein(α 1-AG), ceruloplasmin(CP) on the development of typ e 2 diabetes. Methods Serum IL-6 and TNF-αwas measured by chemiluminesce nt enzyme immunoassay, α 1-AG and CP was measured by velocity scattering turb idimetry in 91 patients with type 2 diabetes and 30 controls. Results The levels of IL-6, TNF-α, α 1-AG and CP in typ e 2 diabetes group were obviously higher than those in control group(P<0.0 1). The levels of IL-6, TNF-α,α 1-AG and CP in type 2 diabetes group with complication were obviously higher than those without complication( P<0.01 or P<0.05). Conclusions The serum levels of IL-6, TNF-α,α 1-AG and CP have correlated with the development of disease in type 2 diabetes.

关 键 词：急性时相蛋白 细胞因子 IL-6 CP 并发症 TNF-Α 2型糖尿病 结论 水平 目的 

分 类 号：R587.1[医药卫生—内分泌] R735[医药卫生—内科学]