类风湿性关节炎患者外周血趋化因子水平的研究  

Study on the levels of some chemokines in peripheral blood of patients with rheumatoid arthritis

作　　者：毛立群[1] 王越[1] 杨静[1] 李瑞民[2] 

机构地区：[1]武警医学院免疫学教研室,天津市300162 [2]承德医学院微生物学教研室

出　　处：《河北医药》2004年第10期771-772,共2页Hebei Medical Journal

摘　　要：目的　加深认识趋化因子在类风湿性关节炎发病机制中的作用 ,并探讨其可能的临床价值。方法　采用酶联免疫吸附试验 (ELISA)分别对 3 0例类风湿性关节炎 (RA)患者和 3 0例健康对照者外周血中MIP 1α、RANTES和MCP 1水平进行检测。结果　RA患者血清MIP 1α、RANTES水平与正常对照组相比均升高 (P <0 .0 1,P <0 .0 5 ) ;而RA患者血清MCP 1水平与正常对照组相比差异无显著性(P >0 .0 5 )。结论　RA患者血清中MIP 1α和RANTES水平的升高可能与其体内Th1 Th2细胞比例失衡及炎症部位Th1细胞浸润有关 ,并且RA患者所发生的慢性关节滑膜炎及血管炎病变可能也与高水平MIPObjective To investigate the action and clinic significance of some chemokines on the pathogenesis of rheumatoid arthritis (RA).Methods The levels of MIP-1α,RNATES and MCP-1 in serum from peripheral blood of 30 patients with RA and 30 healthy subjects were measured respectively by enzyme-linked immunosorbent assay (ELISA).Results The levels of both MIP-1α and RANTES in the serum of patients with RA were higher than those in control group (P<0.01,P<0.05),while there was no significant difference in the levels of MCP-1 between two groups (P>0.05).Conclusions The high levels of MIP-1α and RANTES in the peripheral blood of patients with RA may be associated with the unbalance on the ratio of Th1 to Th2 cells and the infiltration of Th1 cells in the inflammatory tissue.The high levels of MIP-1α and RANTES may also play an important role in the progress of arthritis and endangeitis in RA patients.

关 键 词：患者 RANTES MIP-1Α 类风湿性关节炎 趋化因子 外周血 血清 高水平 结论 失衡 

分 类 号：R593.22[医药卫生—内科学] R692[医药卫生—临床医学]