尿微量蛋白检测对过敏性紫癜患儿早期肾损伤的临床价值  

Detected Urinary Micro-protein for Assessment of Early Renal Damage of Anaphyl actoid Purpura in Child

作　　者：缪美华[1] 邵雪君[1] 冯建国[1] 丁云芳[1] 

机构地区：[1]苏州大学附属儿童医院检验科,江苏苏州215003

出　　处：《江苏大学学报（医学版）》2004年第5期429-431,共3页Journal of Jiangsu University：Medicine Edition

摘　　要：目的 :探讨尿微量蛋白检测对过敏性紫癜患儿早期肾损伤的临床价值。方法 :免疫透射比浊法测定尿M Alb ,β2 MG ,α1 MG ,U TRF和U IgG。结果 :过敏性紫癜患儿组 5项尿微量蛋白检测结果与正常儿童对照组有显著性差异 ,但又与肾炎综合征患儿组存在非常显著性差异 ,5项尿微量蛋白联合检测发现过敏性紫癜患儿有早期肾损伤的阳性率达 5 7 14 %。结论 :尿微量蛋白检测可较好地反映肾损害程度 ,有助于过敏性紫癜患儿早期肾损伤的诊断。Objective:To explore the diagnosis of kidney damag e of anaphylactoid purpura(AP) at the early stage by detecting micro-protein in u rine. Methods:Detecting the M-Alb,β2-MG,α1-MG,U-TRF and U-I gG in urine by immunoturbidimetric assay. Results:The difference o f the detected index between the AP group and nephritic syndrome(NS) group or n ormal control group was significant(P<0.001 and P<0.05 respectively).T he positive rate of binded detecting 5 kinds of differented micro-protein in ur ine was 57.14% to AP childrens who had not any abnormality by examing renal fu nction,ultrasonic scan of the kidney,regular test of urine. Conclusion:The majority of AP has kidney damage, the 5 kinds of micro-protein from ur ine can reflect the condition of kidney involvement sensitively and can be a sen sitive index in determining the kidney involvement at early stage. [

关 键 词：过敏性紫癜 尿微量蛋白 肾损伤 儿童 

分 类 号：R726.9[医药卫生—儿科]