焦炉工职业性多环芳烃暴露特征的研究  

Occupational exposure profiles of polycyclic aromatic hydrocarbons in coke oven workers

作　　者：陈波[1] 郑力行[1] 胡云平[1] 陈亮[1] 荣顺兴[1] 贾琳[1] 王宁[1] 董琛[1] 周袁芬[1] 金泰廙[1] 

机构地区：[1]复旦大学公共卫生学院公共卫生安全国家教委重点实验室,上海200032

出　　处：《中华劳动卫生职业病杂志》2004年第5期327-330,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家973重大科技攻关计划项目(2002CB512905)

摘　　要：目的 探讨焦炉工职业性多环芳烃暴露特征。方法 个体采样、高效液相色谱法测定作业环境中多环芳烃含量,以分析焦炉工职业暴露特征,并引入毒性当量因子概念,评价焦炉工职业性多环芳烃暴露的致癌潜能。结果 焦化厂炉顶工多环芳烃职业暴露水平明显高于炉侧工和炉底工,差异有统计学意义(P<0.05);焦炉工多环芳烃职业暴露中非致癌性物质所占比例>70％,致癌性物质中苯并(a)芘(B[a]Py)占总B[a]Py等当量浓度的65.5％-72.4％;多环芳烃职业暴露总量和B[a]Py及芘含量呈正相关(r2分别为0.84和0.94,P<0.05)。结论 焦炉工职业性多环芳烃暴露水平较高且具有一定的致癌潜能,致癌性物质以B[a]Py为主。Objective To study the characteristics of occupational exposure of polycyclic aromatic hydro-carbons(PAHs) in coke oven workers. Methods Samples were collected individually and PAHs concentration in the ambient air were assayed by high performance liquid chromatography (HPLC) and toxic equivalency factors ( TEFs) were introduced to assess the carcinogenic potency . Results The levels of PAHs occupational exposure in oven workers at topside was higher than at sideoven and bottom oven( P < 0.05) , Non-carcinogenic PAHs were more than 70% of total PAHs and benzo[a]pyrene accounted for 65.5% -72.4% of total benzo[a]pyrene equivalents . Total occupational exposure level of PAHs in coke oven workers was positively related to the content of benzo [a]pyrene and pyrene,respectively( r2 = 0.84, r2 - 0.94, P < 0.05). Conclusion Coke oven workers were exposed to a high level of PAHs which possessd some extent of carcinogenic potency, and benzo[a]pyrene is the chief carcinogenic substance.

关 键 词：焦炉工 职业暴露 职业性 致癌性 高效液相色谱法 苯并(A)芘 多环芳烃 毒性当量因子 焦化厂 采样 

分 类 号：R131[医药卫生—劳动卫生]