宣威县肺癌高发区室内空气不同粒径颗粒物的致突变性与致癌性  

Mutagenicity and Carcinogenicity of Size-Fractionated Indoor Air Particles from the Areas with High Incidence of Lung Cancer in Xuanwei County

作　　者：余淑懿[1] 关迺源 张冬生[1] 郭海恩[1] 李杰[1] 徐坤[1] 治红 赵光礼 

机构地区：[1]中国预防医学科学院环境卫生与卫生工程研究所,北京100050

出　　处：《环境与健康杂志》1993年第2期49-52,共4页Journal of Environment and Health

摘　　要：我们采用Ames试验和中国地鼠卵巢细胞(CHO细胞)姐妹染色单体交换(SCE)测试系统对宜威县肺癌高发区室内空气中不同粒径颗粒物进行了致突性研究。采用二阶段皮肤致癌试验测定其致癌性。结果表明:各粒径颗粒物均有致突变性和致癌性,颗粒物粒径越小其致突变性和致癌性越强。Ames Salmonella assay and sister chro-matid exchanges in CHO cell were used to study the mutagenicity of Size-fractionated indoor air particles from the areas with high incidence of lung cancer in Xuanwei county.Two states skin tumor test was used to study the Carcinogenicity.The results indicate that:all size-fractionated Particles have mutagenicity and carcinogenicity,the more the size is smaller,the more the mutagenicity and carcinogencity is stronger.

关 键 词：室内空气污染 致突变性 肺癌 

分 类 号：R126.8[医药卫生—环境卫生学]