清眩丸质量标准初探  

Studies on quality standard of Qingxuan pills

作　　者：谷学新[1] 毛彦杰[1] 岳敏[1] 范国强[2] 段豫萍[2] 秦晨[2] 

机构地区：[1]首都师范大学化学系,北京100037 [2]北京同仁堂股份有限公司科学研究所,北京100011

出　　处：《中国药学杂志》2004年第10期786-787,共2页Chinese Pharmaceutical Journal

摘　　要：目的建立清眩丸的质量标准.方法采用TLC对处方中白芷、川芎进行定性鉴别;用HPLC测定欧前胡素的含量.结果在TLC中均能检出白芷、川芎;欧前胡素在0.0182～0.0910μg·mL-1内具有良好的线性关系,r=0.999 9,平均回收率为99.52%,RSD=2.37%(n=5).结论所建立的方法简便、准确、可靠,可作为控制该药品的质量标准,本品每丸含白芷以欧前胡素计,不得少于0.3 mg.OBJECTIVE: To establish the quality standard of Qingxuan pills. METHODS: Radix Angelicae Dahuricae and Rhizoma Chuanxiong were determined by TLC. The content of imperatorin was determined by HPLC. RESULTS: Radix Angelicae Dahuricae and Rhizoma Chuanxiong were checked out by TLC. The linear range of imperatorin was 0.018 2 - 0.091 0 μg&middotmL-1 with a good correlation coeffecient (r = 0.999 9). The recovery was 99.52%, and RSD was 2.37% (n = 5). CONCLUSION: The method is simple, accurate and credibile. The method was acceptable as the quality control standard of Qingxuan pills.

关 键 词：清眩丸 欧前胡素 质量标准 

分 类 号：R927.1[医药卫生—药学]