丹参注射液对动脉粥样硬化大鼠血脂及细胞间粘附分子-1表达的影响  

Influence of salvia miltiorrhiza injection on lipid and ICAM-1 expression in rats with atherosclerosis

作　　者：张梅[1] 温进坤[2] 孙辉臣[1] 徐铮[1] 修贺明[1] 

机构地区：[1]河北省石家庄市白求恩国际和平医院中心实验科,河北石家庄050082 [2]河北医科大学基础医学研究所生化研究室,河北石家庄050017

出　　处：《中国病理生理杂志》2004年第10期1871-1873,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :研究丹参注射液对大鼠动脉粥样硬化 (AS)的治疗作用及其作用机制。方法 :采用高脂饲料加大剂量VitD3 复制大鼠AS模型 ,用全自动生化分析仪检测血清甘油三酯、总胆固醇含量。用Westernblot和RT -PCR方法分别检测动脉壁细胞间粘附分子 - 1(ICAM - 1)蛋白及mRNA含量。结果 :丹参注射液组大鼠血清甘油三酯、总胆固醇明显低于AS大鼠 ,丹参注射液组大鼠血管壁ICAM - 1蛋白及mRNA的表达显著低于AS大鼠。结论 :丹参注射液可抑制动脉粥样硬化大鼠血脂及ICAM -AIM: To study the effect of Salvia miltiorrhiza injection on rat atherosclerosis (AS), and elucidate the possible mechanism. METHODS: Wistar rats were fed with fat-rich diet and high dose of vitamin D_3 to induce AS, then treated with Salvia miltiorrhiza injection. Concentrations of triglyceride (TG) and total cholesterol (TC) in serum were measured by automatic serum biochemical assay. The level of ICAM-1 protein and mRNA were determined by Western blot and RT-PCR. RESULTS: Compared with the AS model group, the levels of TG and TC in serum were significantly lower in Salvia miltiorrhiza injection group (P<0.05). Western blot and RT-PCR showed that the level of ICAM-1 protein and mRNA were decreased in Salvia miltiorrhiza injection group compared with AS group. CONCLUSION: Salvia miltiorrhiza injection decreases blood lipid and reduces the ICAM-1 gene expression in rats with atherosclerosis. [

关 键 词：动脉硬化 细胞粘附分子 丹参 

分 类 号：R543[医药卫生—心血管疾病]