熔融共聚法用外消旋乳酸直接合成聚乙醇酸-乳酸及其表征  

Direct synthesis of poly(glycolic acid-lactic acid) from D, L- lactic acid via melt polycondensation and its characterization

作　　者：汪朝阳[1] 赵耀明[1] 王方[1] 

机构地区：[1]华南理工大学材料学院

出　　处：《现代化工》2004年第10期28-30,32,共4页Modern Chemical Industry

基　　金：高等学校博士学科点专项科研基金资助(98056110)广东省自然科学基金资助(020885)项目

摘　　要：以乙醇酸(GA)、廉价的外消旋乳酸(D,L-LA)为原料,以氯化亚锡(质量分数0.5％)为催化剂,在165℃、70 Pa下熔融聚合10 h,通过熔融共聚法直接合成了不同配比的系列生物降解材料聚乙醇酸-乳酸(PGLA),用凝胶渗透色谱、傅里叶变换红外光谱、核磁共振氢谱、差示扫描量热分析、X射线衍射等系统地对其进行了表征。当n(GA):n(D,L-LA)=1:1,直接熔融聚合法获得的D,L-PGLA 50／50的重均相对分子质量为24 300,比相同条件下合成的L-PGLA 50／50的18 000要高。Starting from glycolic acid (GA) and D, L-lactic acid (D, L-LA) catalyzed by 0.5% (percent of weight) of SnCl2, at 165°C and under 70 Pa, a series of biodegradable material poly (glycolic acid-lactic acid) from different molecular feed ratio were directly synthesized via 10 hours' melt polycondensation. The series of D, L-PGLA were characterized by using GPC, FT-IR, 1HNMR, DSC and XRD. When n (GA): n (D, L-LA) = 1:1, the weight-average relative molecular weight (Mw) of D,L-PGLA 50/50 is 24300, which is higher than that of L-PGLA 50/50 (Mw = 18000) under the same synthetic condition.

关 键 词：外消旋乳酸 聚乙醇酸-乳酸 直接熔融聚合 药物缓释载体 

分 类 号：O63[理学—高分子化学] TQ316.3[理学—化学]