A Novel Reductive Cyclization of o-Nitrobenzamides and Ketones Promoted by Low-valent Titanium Reagent  

作　　者：史达清 荣良策 王菊仙 庄启亚 屠树江 

机构地区：[1]Department of Chemistry, Xuzhou Normal University , Xuzhou, Jiangsu 221116, China The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou, Jiangsu 221116, China [2]Department of Chemistry, Xuzhou Normal University , Xuzhou, Jiangsu 221116, China

出　　处：《Chinese Journal of Chemistry》2004年第7期743-746,共4页中国化学（英文版）

基　　金：Project supported by the Natural Science Foundation of Education Committee of Jiangsu Province (No. 03KJB150136).

摘　　要：A short and facile synthesis of a series of 1,2-dihydroquiazolin-4(3H)-ones was accomplished in good yields via novel reductive cyclization of o-nitrobenzamides with ketones promoted by TiCl4/Zn system. The structure was established on the basis of elemental analysis, IR, 1H NMR and confirmed by a single-crystal X-ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.A short and facile synthesis of a series of 1,2-dihydroquiazolin-4(3H)-ones was accomplished in good yields via novel reductive cyclization of o-nitrobenzamides with ketones promoted by TiCl4/Zn system. The structure was established on the basis of elemental analysis, IR, 1H NMR and confirmed by a single-crystal X-ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.

关 键 词：quinazolin-4(3H)-one low-valent titanium o-nitrobenzamide 

分 类 号：O621[理学—有机化学]