硝基化合物和酯一锅法制备酰胺  

One-pot syntheses of amides from nitroarenes and esters

作　　者：祝春兰[1] 邹雪飞[1] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004

出　　处：《浙江师范大学学报（自然科学版）》2004年第3期261-264,共4页Journal of Zhejiang Normal University:Natural Sciences

摘　　要：二碘化钐(SmI2)在四氢呋喃(THF)溶剂中还原硝基化合物,可以生成氮负离子中间体,该中间体具有较高的反应活性.以此为基础,用酰化能力相对较弱的酯作酰化试剂,与硝基化合物通过一锅法以较高的收率合成了酰胺.该制备酰胺的方法具有原料易得、反应条件温和及操作步骤简捷等优点.Nitroarenes can be reduced by samarium diiodide to afford a nitrogen anion,which is a living species and can be acylated by relatively weaker acylating ester agents.Several amides were prepared by means of this approach with a one-pot procedure.The advantages of the method are mild reaction conditions,simplified operational procedure and the raw materials easy to get.

关 键 词：一锅法 中间体 酰胺 制备 四氢呋喃 收率 硝基化合物 反应活性 酰化 反应条件 

分 类 号：N941.5[自然科学总论—系统科学] O623[理学—有机化学]