阿魏酸钠抗花生四烯酸肺栓塞的作用  

Effect of Sodium Ferulate in Preventing Pulmonary Thromboembosis Induced by Arachidonic Acid

作　　者：张军[1] 许澍淮[1] 朱广瑾[1] 金淑敏[1] 周朝风 

机构地区：[1]中国医学科学院基础医学研究所病理生理研究室,北京100005

出　　处：《基础医学与临床》1993年第4期60-63,59,共5页Basic and Clinical Medicine

摘　　要：0.5mg/kg花生四烯酸从免耳缘静脉缓慢注入,成功地复制了可重复的肺栓塞肺动脉高压模型。抗血小板药阿魏酸钠对抗花生四烯酸升高肺动脉压,同时抑制花生四烯酸增加血小板聚集性及增加血浆血栓素A_2、前列环素水平的效应,并明显增加血浆环鸟苷酸水平。The intravenous administration of arachidonate (0.5mg/kg) to rabbit offers a model of rapid, transient and repeatable rise of PAP associated with occlusive platelet aggregates in the microvasculature of the lungs. This model was convenient for the study of antiplatelet drugs. Intravenous administration of sodium ferulate (SF, 50mg/ kg) before arachidonate challenge prevented rise of PAP and decreased occlusive platelet aggregates in the microvasculature of the lung.. The results suggest that the metabolism of TXA2, PGI2 were inhibited and plasma cGMP level was increased both were responsible for the effect of against pulmonary embolism of sodium ferulate.

关 键 词：肺栓塞 花生四烯酸 肺性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]