间断低氧大鼠血和肺组织丙二醛及超氧化物歧化酶活性的变化  

The Changes of Malondialdehyde Contents and Superoxide Dismutase Activities in Blood and Lung Tissue in Intermittent Hypoxic Rats

作　　者：杨文波 孙仁宇[1] 严仪昭[1] 张宏[1] 

机构地区：[1]中国医学科学院基础医学研究所,北京100005

出　　处：《基础医学与临床》1993年第5期41-45,共5页Basic and Clinical Medicine

摘　　要：动态测定了常压间断低氧大鼠血清和肺组织丙二醛(MDA)含量及红细胞和肺组织超氧化物歧化酶(SOD)活性。结果发现随低氧时间延长,肺动脉高压逐渐形成的过程中有肺组织及血中MDA含量显著升高;SOD活性呈现先升高后回降的时相性变化。维生素E对上述变化有一定的缓解作用,而山莨菪碱的作用不明显。提示间断低氧过程中肺部氧自由基生成增多,可能参与了肺动脉高压的发病过程。Serum and lung tissue Malondialdehyde (MDA) contents as well as erythrocyte and lung tissue Superoxide Dismutase(SOD) activities were measured during intermittent exposure to hypoxia in rats. It was found that serum and lung tissue MDA contents obviously increased; erythrocyte and lung tissue SOD activities significantly increased at first and ther decreased or retured to normal level when hypoxic pulmonary arterial hypertension was developed, Vit E showed some alleviatory effect on MDA and SOD changes, but Anisodamine showed no obviously effect on it. The results suggest that in the process of intermittent hypoxia in rats, generation of oxygen free radicals was increased in lung, which may play a role in pathogenesis of pulmonary hypertension.

关 键 词：丙二醛 维生素E SOD 肺性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]