玻璃基生物骨水泥生物活性及抗压强度的研究  

Research on the Bioactivity and Compressive Strength of Glass Based Bone Cement

作　　者：付强[1] 周萘[1] 黄文旵[1] 王德平[1] 张丽英[1] 王波 

机构地区：[1]同济大学材料科学与工程学院,上海200092 [2]上海市建设工程质量检测中心虹口区分中心,上海200434

出　　处：《建筑材料学报》2004年第3期354-359,共6页Journal of Building Materials

基　　金：国家自然科学基金资助项目(50272041);上海市科委纳米专项发展基金资助项目(0144NM064)

摘　　要：以CaO SiO2 P2O5系统生物玻璃和磷酸铵调和液混合制得玻璃基生物骨水泥(GBC),然后利用XRD,FTIR和SEM对GBC的产物晶相、化学组成和内部微观结构进行了分析,并对其抗压强度进行了测试.实验结果表明,GBC中所生成的晶体为具有较高生物活性的类骨状羟基磷灰石(HAP)微晶,且这些微晶主要分布于玻璃粉末的界面之间,其端面尺寸在30～50nm;随着在人体模拟液(SBF)中浸泡时间的增加,GBC的抗压强度逐步增加,在30d时可达到80MPa.Glass based bone cement(GBC) was synthesized by mixing CaO-SiO_2-P_2O_5 based glass powder with ammonium phosphate liquid. Phase compositions, chemical compositions and microstructure of the final products of GBC were measured and observed using X-ray diffraction(XRD),Fourier transform infrared spectroscope(FTIR) and scanning electronic microscope(SEM) respectively. The experiment shows that with a longer immersion time in simulated body fluid(SBF) the glass phase in GBC gradually changes to nano-size bone-like hydroxyapatite(HAP)crystallite with the end plane granularity 30～50 nm. Mechanical testing results show that the compressive strength of GBC increases with the proceeding of immersion in SBF(reaching 80 MPa after 30 d). It is clear that GBC is a desirable biomedical material for the repairing of bone defects with an excellent bioactivity and high (mechanical) strength.

关 键 词：磷酸铵 晶相 生物活性 P2O5 生物玻璃 玻璃粉 微晶 晶体 FTIR SiO2 

分 类 号：TU551.34[建筑科学—建筑技术科学] TQ174[化学工程—陶瓷工业]