益气复智颗粒对多发脑梗死性痴呆模型大鼠脑组织细胞凋亡的影响  

Effect of Yiqi Fuzhi Granule on Apoptosis of Brain Tissue of Dementia Rat Model with Multiple Cerebral Infarction

作　　者：周建英[1] 朱海星[2] 崔龙[3] 王明艳[1] 何永辉 

机构地区：[1]南京中医药大学基础医学院,江苏南京210029 [2]南京脑科医院病理科,江苏南京210029 [3]北京中医药大学基础医学院,北京100029 [4]江苏省兴化市人民医院心血管内科,江苏兴化225700

出　　处：《南京中医药大学学报》2004年第6期346-348,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省教育厅自然科学基金 (99KJB3 60 0 0 6)

摘　　要：目的　观察益气复智颗粒对多发脑梗死性痴呆模型大鼠脑皮质形态学、细胞凋亡的影响。方法　采用颈内动脉注射血栓的方法 ,复制多发梗死性痴呆大鼠模型 ,观察益气复智颗粒 12 .4 2g/kg分别于手术前、手术前后、手术后灌胃对实验动物脑皮质形态学、细胞凋亡的影响。结果　益气复智颗粒能使脑缺血后脑内神经细胞凋亡数目下降。结论　益气复智颗粒具有较好的保护脑神经元 ,阻断脑缺血致神经细胞死亡病理过程的作用。OBJECTIVE To observe the effect of Yiqi Fuzhi Granule on apoptosis of brain tissue of dementia rat model with multiple cerebral infarction. METHOD Dementia rat models with multiple cerebral infarction were made to observe the effect of Yiqi Fuzhi Granule on apoptosis. RESULT The granule could reduce the count of cell apoptosis after cerebral ischemia. CONCLUSION Yiqi Fuzhi Granule is effective in protecting brain neuron and antagonizing the pathological process of apoptosis caused by cerebral ischemia.

关 键 词：多发脑梗死性痴呆 脑皮质 形态学 细胞凋亡 益气复智颗粒 

分 类 号：R285.5[医药卫生—中药学]