9味苦寒药对小鼠胃肠运动与肝肾功能影响的实验研究  

An experimental study on the effects of nine medicinal herbs withthe properties of bitterness and cold on gastrointestinal movement and hepatorenal function of mice

作　　者：邱赛红[1] 李飞艳[1] 尹健康[1] 吴红娟[1] 肖锦仁[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《湖南中医学院学报》2004年第5期1-3,6,共4页Journal of Hunan College of Traditional Chinese Medicine

基　　金：国家自然科学基金项目 ( 3 0 171162 )

摘　　要：目的研究传统认为有伤胃作用的 9味苦寒药对胃肠运动与肝肾功能的影响。方法 9味苦寒药(黄连、山豆根、黄芩、栀子、苦参、黄柏、大黄、汉防己、龙胆草 )水煎剂给小鼠连续大剂量用药 8d ,观察动物一般行为变化、体重、进食量情况、胃排空与胃肠推进和肝肾功能。结果 9味苦寒药用药后 ,动物进食量减少 ,精神较差 ,体重增长缓慢。给药之初动物均出现腹泻 ,但 5d后缓解。各苦寒药物组动物的胃排空及胃肠推进均不同程度降低。 9味苦寒药对血清CR和BUN未见明显影响。黄连、山豆根、栀子、苦参 4药使血清AST活性明显升高。结论传统认为有伤胃作用的这些苦寒药在较大剂量连续用药后确实可致动物胃肠功能紊乱 ;黄连、山豆根、栀子、苦参 4药对肝功能有一定损害。临床需要较长时间大剂量使用这些药物时应引起注意。?Objective To investigate the effects of nine medicinal herbs with the properties of bitterness and cold on gastrointestinal movement and hepatorenal function of mice.Methods Decoction of single herb was prepared respectively from Coptidis rhizoma,Bushy sophora,Soutellaria, Gardenia,Flavescent sophora,Phellodendron,Rhubarb,Fangji and Gentian at first.Then,they were fed to mice for 8 days continuously.During the experimental period,these mice were kept under close observation on the general behavior,body weight,the quantity of taken food,the time of gastric emptying, gastrointestinal movement and hepatorenal function.Results Following feeding with these herbs,all the experimental animals showed reduced diet,poorer mind and slowed down increasing rate of body weight.Furthermore,the animals all manfested diarrhea at the first 5 days of experiment, and then, it began to disappear.Gastrointestinal movement was slowed down at various degrees among all the groups of animals and no significant effects were seen on the serum levels of CR and BUN.However,Coptidis rhizoma,Bushy sophora,Gardenia and Flavescent sophora cold induce significantly elevated serum level of AST.Conclusion These bitter and cold herbs tested here can induce dysfunction of grastrointestinal system when used in a higher dosage for a continuous period of time.Furthermore, some toxic effects can also be seen on hepatic function by use of Coptidis rhizoma,shy sophora,Gardenia and Flavescent sophora.These should be kept in mind when these herbs are to be used in a higher dosage for a longer period of time in clinic.

关 键 词：苦寒药 胃损伤 胃肠运动 肝功能 小鼠 黄连 山豆根 黄芩 龙胆草 

分 类 号：R285.5[医药卫生—中药学]