非典型川崎病冠状动脉声学密度定量研究  

Study of acoustic densitometry technique in detecting coronary arteries in patients with atypical Kawasaki disease

作　　者：韩铁光 黄若谷 吴本清 梁海南 熊奕 

机构地区：[1]广东省深圳市卫生局科研处,518020 [2]暨南大学附属第二医院,广东省深圳市人民医院儿科,518020 [3]暨南大学附属第二医院,广东省深圳市人民医院超声科,518020

出　　处：《广东医学》2004年第11期1266-1267,共2页Guangdong Medical Journal

基　　金：广东省深圳市科研基金资助项目 (编号 :2 0 0 2 -0 40 3 40 )

摘　　要：目的　探讨非典型川崎病 (KD)冠状动脉声学密度定量改变的临床意义。方法　非典型KD患者 2 5例 (KDⅠ组 ) ,典型KD患者 30例 (KDⅡ组 ) ,其他发热患者 2 0例 (发热组 ) ,正常对照组 30例 ,应用SONOS - 5 5 0 0型超声诊断仪检测冠状动脉壁背向散射积分 (IBS)。结果　KDⅠ组 ,KDⅡ组 ,发热组及对照组左冠状动脉的IBS分别为 4 3 31± 4 15 ,4 2 17± 3 95 ,34 92± 3 87,34 34± 4 18;右冠状动脉IBS分别为 4 1 39± 4 91,4 0 92± 3 76 ,31 6 2±6 2 7,31 2 0± 7 2 1。KDⅠ组IBS与KDⅡ组比较差异无显著性 (P >0 0 5 ) ,与发热组、对照组比较差异有显著性 (P <0 0 5 )。结论　非典型KD早期存在冠状动脉IBS异常改变 ,声学密度定量技术有助于非典型KD的早期诊断。Objective To investigate the clinical significance of acoustic densitometry technique in detecting the changes of coronary arteries in patients with atypical Kawasaki disease(KD). Methods 25 patients with atypical KD were assigneel into KD Ⅰ group;30 patients with typical KD in KD Ⅱ group;20 patients with fever caused by other disease in fever group;30 normal children as control group. The integrated backscatter(IBS) of coronary arteries was measured in four groups with Agilent SONO-5500 ultrasound diagnostic system. Results The IBS of left coronary arteries in KD Ⅰ,KD Ⅱ, fever and control groups was 43.31±4.15,42.17±3.95, 34.92±3.87 and 34.34±4.18 respectively; The IBS of right coronary arteries in KD Ⅰ,KD Ⅱ, fever and control groups was 41.39±4.91,40.92±3.76,31.62±6.27,31.20±7.21 respectively. There was no significant difference of IBS between KD Ⅰ and KD Ⅱ groups(P>0.05); the IBS in KD Ⅰ and KD Ⅱ groups was significantly higher than that in fever and control group(P<0.05). Conclusion The IBS of coronary arteries in patients with atypical KD is abnormal. Acoustic densitometry technique is helpful in the diagnosis of atypical Kawasaki disease at early stage.

关 键 词：KD 冠状动脉 IBS 声学密度定量 对照组 非典型川崎病 患者 结论 显著性 差异 

分 类 号：R725.97[医药卫生—儿科] R542[医药卫生—临床医学]