圣约翰草提取物与氟西汀对照治疗脑卒中后抑郁65例  

Comparison of San John'Wort extract with fluoxetine in the treatment of post-stroke depression

作　　者：莫卫焱[1] 于海燕 杨毅 

机构地区：[1]大连医科大学附属第四医院,大连116001 [2]大连市第二医院,大连116011 [3]大连铁路疗养院,大连116032

出　　处：《中国新药杂志》2004年第10期942-944,共3页Chinese Journal of New Drugs

摘　　要：目的:评价圣约翰草提取物治疗脑卒中后抑郁(PSD)的疗效及安全性。方法:65例PSD患者随机分为治疗组32例及对照组33例,分别服用圣约翰草提取物450mg·d-1,po,tid和氟西汀20mg·d-1,po,qd,疗程均为6周。疗效评价采用汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)和评价日常生活能力量表(ADL)。安全性评价采用不良反应量表(TESS)、实验室检查及体检。结果:治疗组治疗PSD有效率为84.4％,对照组为81.8％,两组之间差异无显著性(P>0.05)。而且圣约翰草提取物可促进卒中后神经康复,两组常见不良反应较轻,不良反应发生率差异无显著性(P>0.05)。结论:圣约翰草提取物治疗脑卒中后抑郁有较好的疗效,可促进卒中后神经康复,不良反应轻,安全性高。Objective:To evaluate the efficacy and safety of San John'Wort extract (Neurostan)in the treatment of post-stroke depression (PSD). Methods:Sixty five PSD patients were randomly assigned to either treatment group orally receiving Neurostan at 450mg tid daily (n = 32) or control group receiving fluoxetine at 20mg qd daily (n =33) for 6 weeks. The efficacy evaluation was based on Hamilton Depression Scale (HAMD), Self-depression Scale (SDS) and a survey on quality of life (ADL). The safety profile was evaluated with Treatment Emergent Symptoms Scale (TESS). Results: Neurostan patients showed a 84. 4% response versus a 81. 8% response for fluoxetine (P >0. 05). Neurostan and fluoxetine have not shown significant difference in side effects (P>0.05). Conclusion: Neurostan appears to be effective and safe against post-stroke depression.

关 键 词：圣约翰草 脑卒中后抑郁 提取物 不良反应 治疗 氟西汀 神经康复 促进 差异 目的 

分 类 号：R282[医药卫生—中药学] R743[医药卫生—中医学]