海藻酸钙凝胶微球中模型药物的pH值依赖性释放  

pH-Sensitive release of modern drug from Ca-alginate gel beads

作　　者：马萍[1] 孙淑英[2] 辛艳茹[1] 梁冬梅[1] 高文静[1] 

机构地区：[1]第二炮兵总医院药剂科,北京100088 [2]沈阳药科大学药学院,辽宁沈阳100016

出　　处：《中国医院药学杂志》2004年第11期681-682,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :考察海藻酸钙凝胶微球中模型药物的 pH值依赖性释放。 方法 :以硝苯地平为模型药 ,采用滴制法制备了含药微球 ;考察了含药微球在不同 pH值介质中的释放特性。结果 :含药微球在水及 pH 1 .0的介质中几乎不溶胀 ,1 2h累积释放百分率为 2 3.1 %和 2 3.4 %;在 pH6 .8的介质中微球溶胀至完全溶蚀 ,且呈现缓慢释放的趋势 ,1 2h药物的累积释放百分率为 92 .5 %;换介质的释放中 ,0～ 2h微球几乎不溶胀 ,2h累积释放 8.4 %,介质 pH改变后微球很快崩解 ,3h累积释放82 .4 %。结论 :海藻酸钙凝胶微球中硝苯地平的释放具有 pH值依赖性 ,在 pH6 .8的介质中缓释。OBJECTIVE To study pH-Sensitive release of modern drug from Ca-alginate gel beads. METHODS Ca-alginate gel beads containing the model drug nifedipine(NP) were prepared by dropping method; At the same time, release property of drug beads were studied. RESULTS In distilled water and 0.1 mol·L -1 HCL(pH 1.0) solution,the release amount of NP from the beads was 23.1% and 23.4% at 12 h, in phosphate buffer (pH 6.8) the date was 92.5% at 12 h. In change media test,the date were 8.4% at 2 h and 82.4% at 3 h. CONCLUSION Release of nifedipine from Ca-alginate gel beads had pH-sensitive property,NP Ca-alginate gel beads was sustained-release beads in phosphate buffer (pH 6.8).

关 键 词：海藻酸钙 凝胶微球 pH值依赖性释放 硝苯地平 

分 类 号：R944.9[医药卫生—药剂学]