甲氧氯普胺对吗啡依赖小鼠血清和脑区cAMP含量的影响  

Effects of Metoclopramide on cAMP of Serum and Brain Areas in Morphine-Dependent Mice

作　　者：陈一燕[1] 陈崇宏[2] 

机构地区：[1]福建医科大学附属厦门第一医院药学部,厦门361003 [2]福建医科大学药理学教研室,福州350004

出　　处：《海峡药学》2004年第5期53-55,共3页Strait Pharmaceutical Journal

摘　　要：目的 　观察甲氧氯普胺 ( metoclopramide,Meto)对吗啡依赖小鼠血清和脑区环磷腺苷 ( c AMP)含量的影响。方法 　皮下注射吗啡建立小鼠吗啡身体依赖模型 ,以放射免疫法测定小鼠血清和脑区 c AMP含量。结果 　吗啡依赖小鼠小脑、海马和丘脑等三个脑区和血清中 c AMP含量均低于正常小鼠 ;Meto急性给药 ( 2 0 mg· kg- 1 ,ip)使吗啡依赖小鼠大脑皮层的含量显著升高 ,且高于正常鼠 ,其余脑区数值与依赖鼠无区别 ,血清 c AMP含量升高接近正常值。 结论 　 Meto可使吗啡依赖小鼠的大脑皮层和血清 c AMP含量升高。OBJECTIVE To study the effects of metoclopramide (Meto)on the cAMP of serum and brain areas in morphine-dependent mice.METHODS The concentrations of cAMP were determined in naive mice and the mice treated with morphine or/and Meto with radioimmunoassay.RESULTS Compared with those in naive mice, concentrations of cAMP in serum, cerebellum, hippocampus and thalamus decreased significantly, while the cAMP concentrations in cerebral cortex and serum of morphine-dependent mice treated with single dose of Meto(20 mg·kg -1 ,ip)increased significantly.CONCLUSION Meto could increase the cAMP level in cerebral cortex and serum of morphine-dependent mice.

关 键 词：甲氧氯普胺 吗啡依赖 小鼠 CAMP 

分 类 号：R965[医药卫生—药理学] R963[医药卫生—药学]