HLA-I类抗原与HFRS的相关性研究  

Study of relationship between genetic polymorphism of HLA-I antigen and HFRS

作　　者：盖中涛[1] 刘洋[2] 张颖[1] 张永[1] 

机构地区：[1]济南市传染病医院,山东济南250021 [2]济南市中心医院中心实验室

出　　处：《山东医药》2004年第32期16-17,共2页Shandong Medical Journal

基　　金：济南市科委立项课题 (0 2 10 3 8)

摘　　要：目的　探讨 HL A- 类基因多态性与肾综合征出血热 (Hemorrhagic fever with renal syndrome,HFRS)的相关性。方法　应用微量淋巴毒试验对中国北方地区 5 6例 HFRS患者 (HFRS组 )及健康人群 (对照组 ) HL A- 类基因频率分布进行了检测。结果　 HFRS组 HL A- B39和 HL A- B4 0抗原出现频率均为 7.14 % ,对照组皆为 0 ,两组比较差异具有显著性 (P<0 .0 5 )。结论　HL A- B39和 HL A- B4 0基因可能与中国北方地区人群HFRS的易感性有关。Objective To evaluate the relationship between genetic polymorphism of HLA-Ⅰ antigen and hemorrhagic fever with renal syndrome(HFRS).Methods 56 cases of patients with HFRS (HFRS group) were detected by lymphoctytotoxic test as well as 96 cases of normal controls.Results The frequency of both HLA-B39 and HLA-B40 were 7.14% in the HFRS group,which were significantly higher than those in the control group(P<0.05).Conclusion HLA-B39 and HLA-B40 held by people in north China might be related to the susceptivity of HFRS.

关 键 词：HFRS HLA-B HLA-I类抗原 对照组 相关性研究 淋巴 肾综合征出血热 结论 显著性 目的 

分 类 号：R512.8[医药卫生—内科学] R734.2[医药卫生—临床医学]