β-榄香烯海藻酸钙-壳聚糖微囊的制备  

Preparation of β-Elemene Calcium Alginate-Chitosan Microcapsules

作　　者：李胜[1] 许有威[2] 任东文[1] 郑建华[1] 马小军[1] 

机构地区：[1]中国科学院大连化学物理研究所生物医学材料工程研究组 [2]大连医科大学药学院药物分析教研室,辽宁大连116027

出　　处：《中国医药工业杂志》2004年第11期657-660,共4页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(20176056)

摘　　要：采用乳化-内部凝胶化技术制得载b-榄香烯的海藻酸钙凝胶微球,然后与壳聚糖反应制得b-榄香烯海藻酸钙-壳聚糖微囊。利用激光共聚焦扫描显微镜和激光粒度仪观测所得微囊的形态、粒径及分布,通过气相色谱法考察体外释放性能。结果表明制品球形度好、膜层均匀,粒径呈正态分布,体外释放曲线符合Higuchi方程。b-Elemene calcium alginate gel microspheres were prepared by emulsification-internal gelatificationtechnology, and then microspheres reacted with chitosan solution to obtain b-elemene calcium alginate-chitosan microcapsules.The shape, diameter and size distribution of the microcapsules were investigated using confocal laser scanning microscopeand laser diffraction particle size analyzer, respectively. In vitro drug release property was examined using gas chromatography.The results showed that b-elemene microcapsules were spherical with uniform membrane thickness and diameters of normaldistribution. The in vitro release property of b-elemene from microcapsules was fitted to the Higuchi kinetics equation.

关 键 词：Β-榄香烯 海藻酸钙-壳聚糖微囊 乳化-内部凝胶化 

分 类 号：R944.9[医药卫生—药剂学] R979.19[医药卫生—药学]