瑞格列奈的化学结构测定  

Determination of Chemical Constituent and Configuration of Repaglinide

作　　者：李语如[1] 顾萍[2] 陈永江[1] 

机构地区：[1]江苏恒瑞医药股份有限公司,江苏连云港222002 [2]江苏豪森药业股份有限公司,江苏连云港222006

出　　处：《中国医药工业杂志》2004年第11期677-679,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用元素分析、红外光谱、紫外光谱、氢核磁共振谱、碳核磁共振谱、质谱、热重和差热分析、粉末X-射线衍射、比旋度、液-质联用等方法研究了瑞格列奈的化学结构,并对所得图谱和数据进行解析,结果与文献一致。The element analysis, IR, UV, 1HNMR, 13CNMR, MS, TG, DSC, X-ray powder diffraction, [a]D andHPLC-MS were used for determination of the chemical constituent and configuration of repaglinide. The pattern and datacan be explained. The results showed that the chemical structure of repaglinide accorded with the data of S-(+)-isomerreported in literature.

关 键 词：瑞格列奈 结构测定 

分 类 号：TQ460.72[医药卫生—药物分析学]