桃仁、红花不同配比的血府逐瘀汤对大鼠急性心肌缺血的保护作用  

Study of the Protective Effects and Mechanisms of Xuefu Zhuyu Decoction of Different Compatible Proportions of Taoren and Honghua on Acute Myocardial Ischemia in Rats

作　　者：张秋雁[1] 苏剑锋 周小青[3] 王大安[3] 刘新华[3] 张玉生[3] 

机构地区：[1]湖南中医学院中医诊断研究所 [2]湖南省耒阳市武警8730部队医院 [3]湖南省中医学院诊断研究所

出　　处：《中西医结合心脑血管病杂志》2004年第11期649-650,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：湖南省教育厅基金立项 (No .0 3C2 97);湖南中医学院中医诊断学国家重点学科资助项目

摘　　要：目的　探讨桃仁、红花不同配比的血府逐瘀汤对大鼠急性心肌缺血的保护作用。方法　采用大鼠舌下静脉注射垂体后叶素造成急性心肌缺血模型 ,观察桃仁、红花不同配比的血府逐瘀汤对实验性心肌缺血大鼠血清一氧化氮(NO)、内皮素 (ET)、超氧化物歧化酶 (SOD)、丙二醛 (MDA)含量的影响。结果　桃仁、红花不同配比的血府逐瘀汤均可以明显提高血清NO、SOD的含量 ,显著降低ET、MDA含量 (P <0 .0 5～0 .0 1) ,各给药组之间无明显差异。结论　桃仁、红花不同配比的血府逐瘀汤对急性心肌缺血大鼠均具有保护作用。Objective To investigate the protective effect of different proportions of compatible application of Taoren and Honghua of Xuefu Zhuyu Decoction on acute myocardial ischemia in rats.Methods Pituitrin was injected into dorsal veins of tongue to reproduce the model of acute myocardial ischemia. The contents of NO、ET、SOD and MDA in serum were observed.Results Xuefu Zhuyu Decoction of different compatible proportions of Taoren and Honghua could significantly enhance the contents of NO and SOD,while reduce the levels of ET and MDA(P<0.05～0.01). The differences among the groups were not significant.Conclusion All the Xuefu Zhuyu Decoctions of different compatible proportions of Taoren and Honghua have protective effect on acute myocardial ischemia in rats.

关 键 词：桃仁 血府逐瘀汤 大鼠 急性心肌缺血模型 保护作用 红花 含量 内皮素(ET) 血清一氧化氮 舌下静脉 

分 类 号：R285[医药卫生—中药学]