^(188)Re-CL58多次小剂量RIT初探  

Preliminary Study on Multiple Low Dose With ^(188)Re-CL58

作　　者：丁勇[1] 田嘉禾[1] 杨志 陈英茂[1] 张书文[1] 徐发良[3] 

机构地区：[1]中国人民解放军总医院核医学科,北京100853 [2]北京大学肿瘤医院核医学科,北京100036 [3]中国人民解放军,北京100850

出　　处：《同位素》2004年第3期139-142,共4页Journal of Isotopes

基　　金：军队95课题资助项目(96M135)

摘　　要：采用放射免疫治疗(RIT)法治疗荷肺腺癌小鼠,观察RIT时多次小剂量给药方式的药物分布特点和抑瘤效果。结果显示,在总剂量相同的条件下,多次小剂量RIT组的放射性标记抗体在肿瘤部位的摄取量(总的累积活度)比单次大剂量RIT组高,且更能减轻肿瘤负荷并明显抑制肿瘤转移。多次小剂量RIT组小鼠体重减少及瘤重均明显小于对照组和单次大剂量RIT组(P<0.05);多次小剂量RIT组肺转移结节数明显低于对照组和单次组(P<0.05)。因此,在不增加总剂量的情况下,多次小剂量RIT能提高肿瘤部位的照射剂量。多次小剂量RIT疗效优于单次大剂量RIT。The tumor-bearing mice are treated with ^(188)Re-CL58 by radioimmunotheray(RIT). The tumor controlling effect and drug distributing characteristics are observed. The results show that the uptake of tumor are more than that of normal tissue. The tumor suppressions effects of multiple low dose (MLD)-RIT group are more significantly than those of single high dose (SHD)-RIT and control group. MLD-RIT group suffers less weight loss and the least less-weighted tumors than control group and SHD-RIT group (P<0.05). For the numbers of metastatic foci, MLD RIT group have also less than both control group and SHD group (P<0.05). Tumors of MLD-RIT group absorbed more radiation dose than SHD-RIT group after injected the same dose of ^(188)Re-CL58. It may bring a conculsion that the curative effect of MLD-RIT is better than that of SHD-RIT.

关 键 词：放射免疫治疗(RIT) 荷瘤小鼠 多次小剂量 

分 类 号：R730.55[医药卫生—肿瘤] TQ463.4[医药卫生—临床医学]