维芎瘢痕霜对增生性瘢痕影响的临床研究  

The effect of Weixiong Scar Cream on bFGF and FN in hypertrophic scar

作　　者：赵连魁[1] 谷廷敏[2] 刘建春[3] 陶东升[3] 李冬军[1] 

机构地区：[1]石家庄钢铁有限责任公司职工医院烧伤整形科,河北石家庄050031 [2]北京军区总医院 [3]白求恩和平医院

出　　处：《中国实用美容整形外科杂志》2004年第5期249-250,共2页

摘　　要：目的　为了解维芎瘢痕霜对增生性瘢痕内bFGF和FN的影响 ,探讨维芎瘢痕霜防治增生性瘢痕的作用机理。方法　应用免疫组织化学方法 ,对维芎瘢痕霜治疗的 32例患者增生性瘢痕内的bFGF和FN的变化进行观察。结果　 32例增生性瘢痕患者连续应用维芎瘢痕霜 30天和 6 0天时 ,瘢痕内的bFGF和FN较未用药对照部位瘢痕内的bFGF和FN表达明显减少。结论　维芎瘢痕霜可以明显抑制瘢痕内bFGF和FN的表达 ,对增生性瘢痕有防治作用。Objective To investigate the effect of Weixiong Scar Cream on bFGF and FN in hypertrophic scar and to understand the preventive mechanism of Weixiong Scar Ceram to the hypertrophic scar. Methods The immunohisto-chemical method has been used to determined the bFGF and FN expression in the hypertrophic scar of 32 patients examples. Results The expression of bFGF and FN in the hypertrophic scar treated with the Weixiong Scar Cream is much lower than that in the control group during the time of 30 days and 60 days posttreated respectively. Conclusion Weixiong Scar Cream has some effects on preventing hypertrophic scar by inhibiting the bFGF and FN expression.

关 键 词：增生性瘢痕 碱性成纤维细胞生长因子 纤维黏连蛋白 

分 类 号：R622[医药卫生—整形外科]